抑癌基因 的英文怎麼說
中文拼音 [yìáijīyīn]
抑癌基因
英文
antioncogene-
In 2005, researchers at sloan - kettering reported that the gene could stop massie tumor growth in prostate cancer een when another tumor suppressor, known as p53, was turned off
早在2005年，斯隆-凱特琳中心的研究人員就曾報道了在另一種叫做p53的腫瘤抑制基因關閉時，該基因甚至仍然可以阻止前列腺癌大腫瘤生長。8p22 of human chromosome is an region with abundant disease - related genes. it is said that it is susceptible loci of hypertension and schizophrenia. the region is also the loci of oncogene and tumor su - pressor gene
人染色體8p22區是疾病基因富含區域，有報道說該區域是高血壓、精神分裂癥等疾病的易感位點，也是癌基因和抑癌基因的研究熱點。The gene, called rassf1a, is a tumor - suppressor gene
這個基因叫rassf1a基因，是一個抑癌基因。Curcumin has been shown to induce a wide variety of tumor cells by several mechanisms, mainly including modulation of the expression of oncogenes and cancer suppressor genes, down - regulation the activation of transcription factors, via many signal transduction pathways, and the modulation of cell cycle. provides an overview of domestic and international apoptosis mechanisms of malign tumor cells induced by curcumin in order to better explore and open up new avenues of cancer treatment
姜黃素能夠誘導多種腫瘤細胞系凋亡，其機制主要是調控癌基因和抑癌基因，下調多個轉錄因子活性，通過多種信號轉導途徑，誘發細胞周期停滯而誘導細胞凋亡.對近年來姜黃素誘導細胞凋亡的機制進行綜述，以便更好地探求和開辟治療惡性腫瘤的新途徑。Inhibition of liver tumor growth by combining endostatin gene delivery with radiotherapy
轉染內皮抑素基因聯合放射治療對肝癌移植瘤生長的影響Since evidence shows anti - estrogen drugs will fail in a many patients with estrogen - receptor - positive breast cancer, says knudsen, our research suggests that physicians should examine both estrogen receptor status and rb tumor suppressor status during the initial diagnosis, in order to prescribe the most effective therapy for that specific patient ' s cancer.
證據表明，抗雌激素藥物對雌激素受體陽性乳癌將失效，我們的研究提示，為了給那些特殊癌癥患者制定最有效的治療方法，醫生應該在開始診斷時檢測雌激素受體和rb抑癌基因狀況。Since eidence shows anti - estrogen drugs will fail in a many patients with estrogen - receptor - positie breast cancer, says knudsen, our research suggests that physicians should examine both estrogen receptor status and rb tumor suppressor status during the initial diagnosis, in order to prescribe the most effectie therapy for that specific patient ' s cancer.
證據表明，抗雌激素* *物對雌激素受體陽性乳癌將失效，我們的研究提示，為了給那些特殊癌癥患者制定最有效的治療方法，醫生應該在開始診斷時檢測雌激素受體和rb抑癌基因狀況。Germline mutations in the brca1 or brca2 tumour - suppressor genes are strong predictors of breast and / or ovarian cancer development
在brca1或brca2腫瘤抑制基因的種系突變是乳腺癌和/或卵巢癌進展的強烈預測指標。Methods : 1 ) 12h after irradiation, the cell cycle of nih3t3 cells was determined by flow of cytometry and the ratio of alternations in p16 gene exon - 2 was evaluated through pcr - sscp. 2 ) the content of mda, the activities of the sod and gsh - px in the supernatant of nih3t3 cells and the cells were measured by detecting kits immediately after irradiation. 3 ) the level of matrix metalloproteinase - 2 ( mmp - 2 ) in hela cells was detected by western - blotting and dot - blotting 2h after irradiation
具體方法為： （ 1 ）照射后12h ，收集nih3t3細胞，用流式細胞儀檢測各組細胞的細胞周期， pcr - sscp檢測抑癌基因p16的變化； （ 2 ） nih3t3細胞照射后立即收集細胞和細胞上清，用試劑盒測量mda含量和sod 、 gsh - px的活性並觀察其變化； （ 3 ） western免疫印跡和點雜交法檢測照射2h后的各組hela細胞中基質金屬蛋白酶- 2 （ mmp - 2 ）的表達變化。Occurrence of liver carcinoma is a synergistic action by multiple factors which include virus infection, carcinogen, oncogene activation, anti - oncogene inactivation, liver cell apoptosis, failure of proliferation regulation and so on
肝癌的發生是一個多因素協同作用的過程，這個過程中包括病毒感染、致癌物的作用、癌基因的激活和抑癌基因的失活、肝細胞的凋亡和增殖調節失控等多因素多環節。In recent years, studies indicated these molecular markers mainly involved : oncogenes and tumor - suppressor genes mutate or rearrange in some thyroid neoplasms ; the exceptional increasing on the activity of telomerase ; the special proteins which are related to cell cycle regulation or adhesion express excessively ; as well as some special matter which is discovered recently
近年研究表明這些分子標志物主要涉及癌基因或抑癌基因的突變或重排；端粒酶活性的異常增高；一些與細胞周期調控或與粘附有關的特殊蛋白的表達；以及一些新發現的特異物質。Neoplasia, or uncontrolled cellular proliferation, can result either from mutations that " turn on " the oncogenes that stimulate growth, or from mutations that result in loss of tumor suppressor genes and their products that inhibit growth
腫瘤或失去控制的細胞增生是由於突變使癌基因啟動從而促使增生，或者由於腫瘤抑制基因和腫瘤抑制基因產物的缺失。For example, as a direct toxic effect, periodontal iruses and bacteria and their products ( endotoxins or enzymes, for example ) are toxic to surrounding cells and may directly induce mutations in tumor suppressor genes and proto - oncogenes or alter signaling pathways that affect cell proliferation or surial of epithelial cells
例如，作為直接毒性作用，牙周病毒和細菌及在細胞周圍其產生的毒性物質（例如，類毒素或酶類）可直接誘導腫瘤抑制基因和原癌基因突變或者改變細胞信號傳導通路從而影響上皮細胞增殖或存活。Moreover, some oncogenes and tumor suppressor genes are also important in cell cycle regulation ; those include myc, ras, p53, p21 and p16
另外，癌基因和抑癌基因也在細胞周期調控中起到關鍵作用，癌基因如： myc ， ras等；抑癌基因如： p53 ， p21 ， p16等等。8p22 of human chromosome is an region rich in disease - related genes and is also the susceptible loci of oncogenes and tumor suppressor genes
人染色體8p22區是一個富含疾病基因的區域，是癌基因和抑癌基因的研究熱點。This silencing also affects the function of many tumor suppressor genes, which, in their unmethylated state, put the brakes on uncontrolled cell growth
這種沉默也影響許多抑癌基因的功能，這些基因在非甲基化狀態下可以阻止不受控制的細胞生長。Tumor - suppressor genes normally protect cells from becoming cancerous, but the gradual silencing of these genes by abnormal methylation is thought to be an early change in cancer deelopment
抑癌基因通常是阻止細胞腫瘤化，隨著這些基因不正常的甲基化，他們就開始沉默，這被視為腫瘤的早期改變。At present, there is not much study with respect to the functional analysis of testin gene. what we know about is that testin may be a cancer supressing gene. the protein contains three lim domains at c - terminus
目前對testin基因的功能研究還不多，其蛋白c端含有3個lim結構域，可能是一個抑癌基因。Doc - 1r gene is an candidate tumor suppressor gene which was discovered by zhangxue. it can interact with cdk2 specifically and restrain cdk2 transportation into the nucleus, which will block the formation of cdk2 and cyclin complex and hinder the process of cell cycle
Doc - 1r基因是張學等發現的一個候選抑癌基因，它可與cdk2特異性結合，抑制cdk2的入核轉運，使cdk2不能與cyclin形成復合物，從而阻抑細胞周期的進程。Ih ped one, a nove1 mo1ecuar probe onolecuar beason ( mb ) was developed to establish a stwle and precise method for the quanitative analysis of gentic materials such as ing1 inrn from differen cells and rna fonn tobacco mosaic virus. the milization method for mb was studied for the fabrication of dna biosensor and dna chip. ih pall two, a series of inunobilization method such as sol - gel method and ligh polererization method were investigaed for the otilization of bio - molecues and fluorescence dye
本論文各章內容可歸納如下：第一章，根據抑癌基因ing1基因的序列設計併合成了檢測ing1轉錄產物的分子信標（ 5 ' - - tamra - c6 - nh - cgttgatggttccacttctcgtgcgttcaacg - dabcyl - 3 ' ） ，其中tamra代表四甲基羅丹明，為熒光基團， dabcyl代表4 - （對二甲氨基偶氮苯）苯甲酸，為熒光熄滅基團。分享友人