激動劑 的英文怎麼說
中文拼音 [jīdòngjì]
激動劑
英文
activator-
A noncompetitive antagonist prevents the agonist from producing any effect at a given receptor site.
非競爭性拮抗劑可阻止激動劑在特定受體部位產生任何效應。Inverse agonist is a new type of classification
摘要反向激動劑指一種新分類概念。What are the sedatie effects of alpha 2 agonists
2受體激動劑的鎮靜效果機理是什麼？What are the sedative effects of alpha 2 agonists
2受體激動劑的鎮靜效果機理是什麼？Characteristics of inverse agonist action
反向激動劑的藥理效應特徵Conclusions the frequency of clinically important valve regurgitation was significantly increased in patients taking pergolide or cabergoline, but not in patients taking non ? ergot - derived dopamine agonists, as compared with control subjects
結論：與對照組相比，服用培高利特或者卡麥角林的患者臨床上發生重要瓣膜返流的頻率顯著增加，但服用非麥角?生的多巴胺受體激動劑的患者瓣膜返流的發生率卻未增加。Background case reports and echocardiographic studies suggest that the ergot - derived dopamine agonists pergolide and cabergoline, used in the treatment of parkinson ' s disease and the restless legs syndrome, may increase the risk of cardiac - valve regurgitation
背景：病例報告和超聲心動圖研究提示，用於治療帕金森病和不寧腿綜合征的藥物?麥角?生物，多巴胺受體激動劑培高利特和卡麥角林，可能增加發生心臟瓣膜返流的風險。Methods we performed an echocardiographic prevalence study in 155 patients taking dopamine agonists for parkinson ' s disease ( pergolide, 64 patients ; cabergoline, 49 ; and non ? ergot - derived dopamine agonists, 42 ) and 90 control subjects
方法：我們用超聲心動圖對155例正在服用多巴胺受體激動劑（ 64例服用培高利特， 49例服用卡麥角林， 42例服用非麥角?生的多巴胺受體激動劑）治療帕金森病的患者和90例對照組進行了一項流行調查。Results clinically important regurgitation ( moderate to severe, grade 3 to 4 ) in any valve was found with significantly greater frequency in patients taking pergolide ( 23. 4 % ) or cabergoline ( 28. 6 % ) but not in patients taking non ? ergot - derived dopamine agonists ( 0 % ), as compared with control subjects ( 5. 6 % )
結果：與對照組相比（ 5 . 6 % ） ，服用培高利特（ 23 . 4 % ）或者卡麥角林的患者（ 28 . 6 % ） ，臨床上發生重要的任何瓣膜的返流（中到重度， 3級到4級）的頻率顯著升高，而服用非麥角?生的多巴胺受體激動劑的患者（ 0 % ）瓣膜返流的發生率卻未增加。Protein kinase a is camp - dependent kinase, one of the most important signal transduction pathways, plays a pivotal role in growth, differentiation, tumor occur, cell cycle control, etc. pka activators such as camp, 8 - br - camp or phosphodiesterase ( pde ) inhibitor isomethyl butyl xanthine ( imbx ) or purified pka catalytic subunit all can inhibit germinal vesicle breakdown ( gvbd ) and meiotic maturation in mouse oocytes, also in xenopus oocytes
蛋白激酶a （ proteinkinasea ， pka ）是依賴于camp的絲蘇氨酸蛋白激酶，是重要的信號傳導途徑之一，廣泛參與許多生命過程，包括生長、分化、腫瘤發生、細胞凋亡、細胞周期調控等。以小鼠卵母細胞為實驗對象，給予pka激動劑camp 、 8 - br - camp或磷酸二酯酶抑制劑imbx （ isomethylbutylxanthine ）均可抑制小鼠卵母細胞的胚泡破裂及減數分裂成熟。Development of a functional reporter gene assay for the identification of glucagon - like peptide - 1 receptor agonist
1受體激動劑功能性報告基因分析系統的構建The binding characteristics of the opioid ligand
受體激動劑對穩定轉染In these two studies by the same japanese group ( 7, 8 ), the enhanced pressor effects of ephedrine and phenylephrine following an alpha 2 agonist ( clonidine ) were no different between awake and anesthetized ( enflurane and nitrous oxide in oxygen ) patients
在這兩個研究中[ 7 ， 8 ] ，麻黃素和苯腎上腺素在使用- 2受體激動劑（可樂定）后的升壓效果增強在清醒和麻醉（安氟醚和笑氣）病人沒有差別。Can the central sedation lead to respiratory depression
2受體激動劑的中樞鎮靜能導致呼吸抑制嗎？According to behavioral studies in adult rats, intrathecal administration of nociceptin, anandamide and win - 55, 212 ( win - 2 ) ( cannabinoid receptor agonists ) produces an antinoceptive effect in versatile pain models including acute, tonic and chronic pain models ( see mogil & pasternak, 2001 ; pertwee, 2001 for review ). thus, it could be concluded that nociceptin - orll receptor and anandamide - cannabinoid receptor systems constitute an important part of endogenous antinociceptive system. however, cellular mechanisms underlying the actions of orl1 and cannabinoid receptors on nociceptive information transmission in the spinal cord are still unknown
行為學研究也觀察到鞘內注入nociceptin和大麻受體的激動劑如win55 ， 212 - 2 （ win - 2 ） 、 anandamide等均可在多種痛模型上（包括急性痛、持續性痛和慢性痛模型等）產生明顯的抗傷害性作用（ seemogil pasternak ， 2001 ; pertwee ， 2001forreview ） ，由此可見nociceptin ?孤啡肽受體系統和anandamide ?大麻受體系統構成了內源性鎮痛系統的重要組成部分。The patch clamp experiment : the cell - attached and inside - out configurations of the patch - clamp techniques were used to investigate single channel properties of nmd a receptors in the actuely dissociated neurons of the marginal division in the rat striatum, recording the current amplitude. long / short term opening / closing times indexes and the effects of incitants and agonists of the nmd a receptors on those parameters. we find that two types of conductance of 42ps and 20ps were recorded, the 42ps was the advantaged conductance
本研究是在本實驗室以前研究的基礎上，通過膜片鉗（ pachclamp ）觀測sd （ sprague - dawley ， sd ）的mrd上nmda受體通道的電生理特性；繼而對青壯年sd大鼠的mrd 、海馬進行毀損並腹腔注射nmda受體阻滯劑ktm （ ketamine ， ktm ） ，觀察其對大鼠學習記憶能力的影響：對于學習記憶能力下降的老年鼠進一步做顱內定位注射nmda受體激動劑與抑制劑，觀察其在特定部位的作用；最後，應用fmri （ functionalmagneticresonanceimaging ; fmri ）對注射ktm的志願者做學習記憶與痛覺的對比觀察。Recently, some new studies suggest that small cytokine peptide - mimics can function as the agonist or antagonist of cytokine receptor, and these small molecular peptides can be synthesized easily and oral adminstration with high concentration. based on these work, we have tried to set up experiment on tnfa - binding peptides and tnfa mimotopes which may be as leads of tnfa antagonist
近年來的研究發現，小分子細胞因子模擬物具有細胞因子受體激動劑或拮抗劑的作用，且小分子模擬物因容易合成並能夠給予高濃度、可口服等優點使其具有更加廣闊的研發與應用前景。Another interention is the induction of ? - cell " rest " by selectie actiation of atp - sensitie k + ( katp ) channels, using drugs such as diazoxide
另一種方法是選用atp敏感的鉀離子通道激動劑（如氯甲苯噻嗪）誘導靜止的細胞。Another intervention is the induction of ? - cell " rest " by selective activation of atp - sensitive k + ( katp ) channels, using drugs such as diazoxide
另一種方法是選用atp敏感的鉀離子通道激動劑（如氯甲苯噻嗪）誘導靜止的細胞。Effect of intrathecal injection of dopamine agonists antagonists on pain and acupucture analgesia in rats
大鼠鞘內注射多巴胺受體激動劑與拮抗劑對痛及針刺鎮痛的影響分享友人