Such examples are given as the blood filtering principal of hemoglobin, catalysis of enzymes, immune recoglization, prion, glycoprotein and the relationship of structure and function of membrane protein, et al, as well as the applications to medicine
在簡要介紹結構生物學的研究方法的基礎上,主要從分子水平闡述蛋白質和核酸的結構原理、相互作用、結構與功能的關系,通過具體實例闡述血紅蛋白的輸氧機制、
酶的催化機制、免疫分子識別、
朊病毒、糖蛋白、生物膜的結構功能關系等,以及結構生物學在醫學上的應用。
Then she added an antibody that cleared the cells of prions but left the ubiquitins, the proteasome and the waste proteins in place
然後她又向細胞注射了可清除
朊病毒而不傷及降解
酶和水解
酶與廢物的抗體。
By carefully measuring the rate at which proteasomes laboured, she found a clear correlation : as the clumps of prions in the sample got bigger, the proteasomes slowed down
通過測試這些水解酶的工作速率,她發現了一個清晰的關系:當標本中的朊病毒團變大時水解酶的工作便慢了下來。