immature t cell 中文意思是什麼
immature t cell
解釋
幼t細胞-
Dendritic cells are characterized by their ability to efficiently present antigen, and are uniquely equipped to stimulate naive t cell responses. immature dendritic cells acquire antigens from throughout the peripheral body, then migrate to t - lymphocyte - dependent areas of lymph nodes. thus, dendritic cells act as bridges, operating at the interface of innate and acquired immunity
作為機體免疫系統中功能最強的專職性抗原提呈細胞（ antigen - presentingcells ， apc ） ，樹突狀細胞（ dendriticcells ， dc ）能高效地攝取、加工處理和提呈抗原，具有較強的遷移能力，並能顯著地激活初始型t細胞以啟動t細胞免疫應答反應，此外， dc與b細胞以及nk細胞等也存在著相互作用，可見， dc在連接天然免疫和獲得性免疫之間起著非常重要的作用。 -
Cd 14 * monocytes or bone marrow derived hematopoietic progenitor cells cultured with granulocyte - macrophage colony - stimulating factor ( gm - csf ) and il - 4 differentiate into efficient apc with morphology and cell surface molecule expression typical of immature dc. it was demonstrated that a variety of factors ( such as lps, tnf - a, il - 1, monocyte - conditioned medium, and cd40 receptor cross - linking ) induce the maturation of immature dc to mature dc that are much more potent in activating t cells by increasing the expression of costimulatory molecules and cytokines, promoting the migration of dc to draining lymph nodes, and down - regulating the capacity of dc to capture and process antigen
在體外，外周血cd14 ~ +單核細胞和cd34 ~ +骨髓造血前體細胞在粒細胞-巨噬細胞集落刺激因子（ granulocyte - macrophagecolony - stimulatingfactor ， gm - csf ）和il - 4的共同作用下可分化為未成熟dc ，未成熟dc具有強大的攝取和處理抗原的能力，但其抗原提呈能力較弱；未成熟dc在炎性細胞因浙江大竿俗士學位論文潛廷平子汐ilq ， yfax病原成分汐lpsx單核細胞條件培養液或cd40l等作用下可分化為成熟dc 。
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