trans-golgi-network 中文意思是什麼
trans-golgi-network
解釋
順式高爾基網狀系統-
Translocation from endocytic compartments to the cytosol is the essential and rate - limiting step in the intoxication process of most toxins such as ricin, diphtheria toxin, shiga toxin and pseudomonas exotoxin ( pe ). a number of these toxins are transported to trans - golgi network ( tgn ), and in many cases such transport to the tgn is required for the translocation and cytotoxicity. in deed, 5 % of the ricin endocytosed by cells has been shown to reach the tgn
蓖麻毒素進入細胞的機理不甚明了，一般認為是rtb先與細胞膜受體結合，主要經過受體介導的內吞作用進入吞噬體，然後沿著內體、高爾基體、內質網等逆向分泌途徑，有序地運輸到內質網，最後從內質網轉位進入細胞漿，在胞漿內攻擊核糖體，從而抑制蛋白質的合成，導致細胞死亡。 -
Rab7 mediates transport of proteins from early endosome to late endosome or fusion of early endosome with late endosome, while rab9 mediates the retransport of m6pr from late endosome to trans - golgi network. the gtp / gdp - binding ability and intrinsic gtpase activity of rab proteins make them exist in rab - gtp or rab - gdp status. the switching of rabs between gtp - bound ( active ) and gdp - bound ( inactive ) forms requires other regulatory proteins, including guanosine exchange factor ( gef ), gdp dissociation inhibitor ( gdi ) and gtpase activating protein ( gap ), and lays the foundations of rab function
Rab蛋白家族成員和其他小g蛋白一樣可以結合gtp gdp ，在自身gtp酶的水解作用和其他蛋白（ gef 、 gap 、 gdi ）的調節作用下發生gtp （活化狀態）和gdp （無活性）結合形式的轉變；同時rab蛋白也在膜結合性（ membrane - bound ）和胞漿可溶性（ cytosolic ）之間變化，一個變化過程對應著一個功能循環，接著rab蛋白回到初始狀態參與下一個循環。
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